Kavli ScholarMarisa Zallocchi

Dr. Marisa Zallocchi is an Associate Professor at Creighton University whose research focuses on understanding the molecular mechanisms underlying hearing loss and developing innovative therapies to preserve auditory function. Her scientific journey began with a long-standing interest in Usher syndrome, the leading genetic cause of combined deafness and blindness. During her postdoctoral training and independent research career, Dr. Zallocchi investigated how Usher proteins contribute not only to sensory cell structure but also to regulatory pathways essential for inner ear development and function. Her work has expanded the traditional view of Usher syndrome by revealing dynamic protein networks that influence disease progression and variability. Building on these discoveries, Dr. Zallocchi established a translational research program focused on identifying and optimizing therapeutic approaches for hearing loss. Using zebrafish and mammalian models, her laboratory integrates genetic approaches, molecular characterization, and pharmacological screening to identify compounds capable of protecting sensory hair cells and preserving hearing. Her research has led to promising therapeutic candidates targeting multiple forms of auditory injury, including noise-induced and drug-induced hearing loss, advancing strategies toward clinical translation.

At Creighton University’s Translational Hearing Center, Dr. Zallocchi leads a collaborative program bridging fundamental discoveries with therapeutic development. She is committed to mentoring the next generation of scientists through research experiences that foster critical thinking, creativity, and independence. Through her work, Dr. Zallocchi seeks to transform understanding of hearing disorders and develop strategies that prevent hearing loss and improve quality of life for affected individuals.